Crosby's Cure - In support of FoxG1 Research
Donation protected
Follow us on Facebook and Instagram @CrosbysCure
Learn more https://www.foxg1research.org
How you can help:
-Share this website with everyone you know and share the video on your social media!
-Donate via GoFundMe
-Mail a check to: Sophia Phillips, 1017 L Street #253, Sacramento CA 95814
-Venmo: @CrosbysCure
-Sign up for Amazon Smile and select FoxG1 Research Foundation - it’s easy and a portion of all your purchases go to the Foundation.
How your donation will be used:
Organoid Model: $12,000 Validate therapeutics, screen therapeutics, protein expression analysis, FOXG1 mechanistic analysis, gather data for IND.
Mouse Model: $20,250 Validate therapeutics, screen therapeutics, show disease rescue in living animal, investigate dominant negative suspicion,
confirm therapeutic dosage sensitivity, gather data for IND.
Small Molecule Drug Screen: $105,000 Preform RNA-sequencing, identify abnormalities in mRNA transcription to downstream genes, screen molecules to improve mechanistic abnormalities.
Principal Investigator 1: $83,470 Pre-clinical cellular data gather (phenotypic characterization, mitochondria phenotype, metabolic change, protein expression profile, identify downstream FOXG1 mRNA binding sites {downstream gene targets}, AAV gene therapy proof of concept).
Principal Investigator 2: $132,542 Pre-clinical cellular proof of concept haploinsufficiency rescue (endogenous promoter, artificial transcription factor, AAV-9 gene therapy).
Principal Investigator 3: $95,000 Electrophysiology study in mouse line. Identify epileptic abnormalities and therapeutics to target them.
File FDA IND: $1,000 File pre-clinical paperwork to FDA for approval of therapeutic use.
Our Story:
Our son, Crosby, was born with an extremely rare neurological disorder that results in severe intellectual disability. We need your help to raise money to find a cure. With your help, we can get there.
After a healthy pregnancy and natural birth, when our son was 6 months old, my husband Ryan and I received the shocking news that our first and only child, Crosby James Phillips (CJ), has an ultra rare neurodevelopmental condition called FoxG1 syndrome - so rare that only 700 children in the WORLD have it. FoxG1 syndrome results in severe intellectual disability and most children cannot sit, walk, talk, or take care of their basic needs. Children with FoxG1 syndrome often require a feeding tube and develop a debilitating form of epilepsy.
Desperate to fight and change our son’s future, we hit the ground running to find the best researchers and scientists to develop a cure. Time is critical because the brain has the greatest ability to change in the earlier years of life.
Without a cure, Crosby’s future is extremely limited. He is almost 2 years olds and struggles with severe epilepsy and a movement disorder which causes dramatic sleep disturbances (often as few as 2-4 hours of sleep a night). He is unable to sit without assistance, cannot feed himself and has a visual impairment impacting his ability to interact with the world around him.
We are in contact with some of the best researchers, scientists and therapy developers in the rare disease space. There is HOPE. The technology exists, Crosby’s Cure is in reach, and you can help us get there.
What your donation will do:
Our first goal is to raise $500,000 to fund research into Crosby’s mutation and create an investigative team of specialists to develop the groundwork to pursue the following therapies: ASO therapy, gene replacement, gene editing, and small molecule.
We have Crosby’s cells in some of the most prestigious labs in the country, being used by top sciences to develop cutting edge therapies which will materially improve or outright cure this debilitating disease.
Every donation matters and even the smallest donation will make an impact.
Please share this GoFundMe with your network to spread awareness and help save our son from this horrific disease. Follow @CrosbysCure on Facebook and Instagram
We are so grateful for your love and support.
With humble gratitude,
Sophia, Ryan and Crosby (who will one day thank you himself!)
Learn more https://www.foxg1research.org
How you can help:
-Share this website with everyone you know and share the video on your social media!
-Donate via GoFundMe
-Mail a check to: Sophia Phillips, 1017 L Street #253, Sacramento CA 95814
-Venmo: @CrosbysCure
-Sign up for Amazon Smile and select FoxG1 Research Foundation - it’s easy and a portion of all your purchases go to the Foundation.
How your donation will be used:
Organoid Model: $12,000 Validate therapeutics, screen therapeutics, protein expression analysis, FOXG1 mechanistic analysis, gather data for IND.
Mouse Model: $20,250 Validate therapeutics, screen therapeutics, show disease rescue in living animal, investigate dominant negative suspicion,
confirm therapeutic dosage sensitivity, gather data for IND.
Small Molecule Drug Screen: $105,000 Preform RNA-sequencing, identify abnormalities in mRNA transcription to downstream genes, screen molecules to improve mechanistic abnormalities.
Principal Investigator 1: $83,470 Pre-clinical cellular data gather (phenotypic characterization, mitochondria phenotype, metabolic change, protein expression profile, identify downstream FOXG1 mRNA binding sites {downstream gene targets}, AAV gene therapy proof of concept).
Principal Investigator 2: $132,542 Pre-clinical cellular proof of concept haploinsufficiency rescue (endogenous promoter, artificial transcription factor, AAV-9 gene therapy).
Principal Investigator 3: $95,000 Electrophysiology study in mouse line. Identify epileptic abnormalities and therapeutics to target them.
File FDA IND: $1,000 File pre-clinical paperwork to FDA for approval of therapeutic use.
Our Story:
Our son, Crosby, was born with an extremely rare neurological disorder that results in severe intellectual disability. We need your help to raise money to find a cure. With your help, we can get there.
After a healthy pregnancy and natural birth, when our son was 6 months old, my husband Ryan and I received the shocking news that our first and only child, Crosby James Phillips (CJ), has an ultra rare neurodevelopmental condition called FoxG1 syndrome - so rare that only 700 children in the WORLD have it. FoxG1 syndrome results in severe intellectual disability and most children cannot sit, walk, talk, or take care of their basic needs. Children with FoxG1 syndrome often require a feeding tube and develop a debilitating form of epilepsy.
Desperate to fight and change our son’s future, we hit the ground running to find the best researchers and scientists to develop a cure. Time is critical because the brain has the greatest ability to change in the earlier years of life.
Without a cure, Crosby’s future is extremely limited. He is almost 2 years olds and struggles with severe epilepsy and a movement disorder which causes dramatic sleep disturbances (often as few as 2-4 hours of sleep a night). He is unable to sit without assistance, cannot feed himself and has a visual impairment impacting his ability to interact with the world around him.
We are in contact with some of the best researchers, scientists and therapy developers in the rare disease space. There is HOPE. The technology exists, Crosby’s Cure is in reach, and you can help us get there.
What your donation will do:
Our first goal is to raise $500,000 to fund research into Crosby’s mutation and create an investigative team of specialists to develop the groundwork to pursue the following therapies: ASO therapy, gene replacement, gene editing, and small molecule.
We have Crosby’s cells in some of the most prestigious labs in the country, being used by top sciences to develop cutting edge therapies which will materially improve or outright cure this debilitating disease.
Every donation matters and even the smallest donation will make an impact.
Please share this GoFundMe with your network to spread awareness and help save our son from this horrific disease. Follow @CrosbysCure on Facebook and Instagram
We are so grateful for your love and support.
With humble gratitude,
Sophia, Ryan and Crosby (who will one day thank you himself!)
Organizer
Sophia P
Organizer
Sacramento, CA