Foregen

Dear Friends and Supporters of Foregen,

We are preparing for a critical phase in our mission: human clinical trials. Thanks to your continued support, we’ve made tremendous progress, and now we are ready to take on our biggest challenge yet towards developing a regenerative solution for circumcised men.

Why We Need Your Help Now

Human clinical trials are the third phase in our research project. They are the culmination of years of research and perseverance. To ensure the trials’ success, we need your support to accomplish several critical objectives:

Secure a partnership with expert researchers who will oversee and conduct the trials.

Further refine the decellularization and recellularization protocols to ensure precision and effectiveness.

Conduct thorough regulatory inquiries with authorities in the country selected for the trials to ensure compliance and readiness.

Complete the development of a comprehensive surgical protocol that will serve as the cornerstone of our clinical approach.

Identify and partner with a Contract Research Organization (CRO) to manage and execute the trials.

Hire skilled research staff, secure well-equipped facilities, and acquire the necessary instruments to begin the experiments.

Conduct ethical and effective participant recruitment to ensure successful trial execution.

Develop comprehensive contingency plans to mitigate risk and ensure progress continues without interruption.

What’s at Stake

This is not just a small step forward—we’re on the brink of achieving our ultimate goal: to provide a regenerative solution for circumcised men. Human clinical trials may finally prove this novel technique is possible, but it requires your help to get there.

How You Can Help

We aim to raise $100,000 to cover the preparatory stages and initial work of the human clinical trials. Your contributions will directly fund the research, facilities, and partnerships required to make these trials a success.

Every donation brings us closer to our goal and helps us create a future where regenerative medicine can fully restore this vital, missing piece of the male anatomy.

Thank you for believing in our mission. Together, we can truly make history.

Sincerely,

The Foregen Team

Dear Friends and Supporters of Foregen,

We're thrilled to share the significant strides we've made in our sheep trials. Having successfully achieved revascularization and re-epithelialization, we're getting closer to our ultimate goal. But the journey has been a challenging one, and we'd like to share our experiences with you.

The Journey So Far

Our initial trials involved attaching decellularized foreskin samples directly onto the backs of sheep. Unfortunately, due to inadequate blood flow, necrosis occurred in several implantations. But every setback is an opportunity to learn. We went back to the drawing board, refined our approach, and embarked on the next round of trials.

In our subsequent trials, we applied foreskin samples to the udder area of the sheep. We saw encouraging improvements, with revascularization observed in several sheep. Yet, challenges emerged as the sheep started biting and scratching the area.

Our Current Progress

For our latest trials, we've innovated an approach that ensures not just revascularization but also re-epithelialization. By burying the foreskin sample tissue beneath a flap of skin on the sheep, the sheep's body itself became a natural bioreactor, creating a vascular network. This method, if successful in humans, could help us avoid necrosis and promote full tissue integration.

Our final vision is a two-stage surgical technique where the decellularized ECM is partially buried beneath the patient's epidermis, then removed and properly attached in the correct position on the penis. To refine this technique and eliminate uncertainties, we need to conduct a final round of experimentation on sheep, set to begin in September 2023.

Our Ask

We need your help. This crucial final round of experimentation costs approximately $100,000. This will pay for the tissue samples, the sheep, the veterinary specialists, as well as the laboratory space. It's a necessary step before we can move forward to human clinical trials in late 2024. Your support will enable us to conduct these vital experiments, bringing us closer to providing a regenerative solution for circumcised men.

Your support can offset the costs of this vital phase and propel us forward as we approach the final stage of our research. We're deeply encouraged by the progress we've made, and we're excited about the possibilities that lie ahead. Pledge your support today and join our efforts to be the first in history to fully reverse the harms of male circumcision.

Thank you for standing with us. Together, we may make the difference.

Sincerely,

The Foregen Team